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Effect Of Chronic K+ Deficiency On Contractile Properties Of Soleus Muscle

      460 Faculty of Environment and Resource Studies lesterol content was brought about by an expansion of the free cholesterol pool which specifically augments biliary cholesterol excretion.

The C. comosa extract also increase plasma high density lipoprotein (HDL)-cholesterol and decreased plasma low density lipoprotein (LDL)-cholesterol. These results suggest that the C. comosa extract exerts a hypolipidaemic action by acceleration of lipid mobilization from extrahepatic tissue to the liver which subsequently increases excretion of cholesterol via the bile for excretion.

(Published in Journal of Ethnopharmacology 66: 199-204, 1999. Support by a grant from the National Research Council of Thailand.)   EFFECT OF CHRONIC K+ DEFICIENCY ON CONTRACTILE PROPERTIES OF SOLEUS MUSCLE IN RATS: EVIDENCE OF SEX DIFFERENCES Pawinee Piyachaturawat1, Suparporn Muchimapura1, Samaisukh Sophasan1, Surawat Jariyawat1, Chumpol Pholpramool1, Jutamaad Satayavivad2, and Hitoshi Endou3 Department of 1Physiology and 2Pharmacology, Faculty of Science, Mahidol University, 3Department of Pharmacology and Toxicology, School of Medicine, Kyorin University, Tokyo, Japan. Key words : K+ deficiency, sex difference, skeletal muscle                     1.

Alteration in skeletal muscle function of chronically K+-depleted male and female rats were investigated in isolated soleus muscles.                                                                                                                        2. By 16 weeks K+ deficiency, plasma K+ concentrations in both male and female rats were reduced to approximately 2mEq/L, which was accompanied by an approximate 50% reduction in muscle K+ content and a marked increase in muscle Na+ content. These changes were similar in both males and females.

                    3. Plasma creatine phosphokinase activity progressively increased with time in K+-depleted male rats, whereas only a slight increase was observed in female rats.                                                                                4. Maximum isometric twitch tension (Pt) and tetanic tension (Po) of K+-depleted soleus muscles obtained from female rats.

                                                                                                                                            5. After exposure to insulin in low-K+ solution, the contractile tension of soleus from the K+-depleted male rats was suppressed to a greater extent.                                                                                                    6. All alterations in muscle function during chronic K+ depletion were restored to normal after 2 week K+ repletion.

                                                                                                                                                                7. The results suggest that there is a preponderance for male over female rats in developing alterations in skeletal muscle function during chronic K+ deficiency. The changes may be associated with abnormalities of muscle membrane permeability and cellular function. (Published in Clinical and Experimental Pharmacology and Physiology (1999) 26, 323-329.

Support, in past, by a Grant-in-Aid for Overseas Scientific Research from the Ministry of Education, Science and Culture (Japan) and a grant from the National Research Council of Thailand.)


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